cees dekker - An Overview

cees dekker - An Overview

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‘Of course, that's about suitable. I hunt for a Actual physical understanding of biological devices inside a bottom-up way. I feel you can distinguish 3 strains of research in my group for the time being. The 1st concerns chromosome construction: How will you get a metre-prolonged DNA polymer folded and organised in this kind of microscopic cell? We now have developed visualisation tactics that enable us to check how, as an example, SMC proteins loop DNA (movie on Youtube) in order to Construct up chromosomes.

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Deposition and atomic pressure microscopy of particular person phthalocyanine polymers involving nanofabricated electrodes

2010, formulated a new way (‘wedging transfer’) to manipulate nanostructures; very first report of DNA translocation by way of graphene nanopores; and understood hybrid nanopores by directed insertion of α-hemolysin into good-state nanopores

SMC complexes can move Bodily roadblocks bigger than their ring size, indicating a nontopological system for DNA loop extrusion

We use nanofabricated microfluidic structures to pattern spatial boundaries for bacteria and biomimetic vesicles with reconstituted protein networks and this assess the elemental job of spatial confinement within the molecular and mobile stage. Our initiatives include things like the next:

Dynamic ParB–DNA interactions initiate and manage cees dekker a partition condensate for bacterial chromosome segregation

In 1993, as being a younger and keen affiliate professor at Delft University of Technological innovation, I'd initially centered the investigate efforts of my group on measuring the electrical conductance of one conducting-polymer molecule. Within two a long time, we experienced established a device during which one wire of the phthalocyaninepolysiloxane polymer was related in between two carefully spaced steel nanoelectrodes.

Resolving the phase measurement in condensin-driven DNA loop extrusion identifies ATP binding because the stage-producing method

‘The concept that You can find such a point being a commencing, a big bang, is currently an interesting signpost to take into consideration that there was a creator. But more usually, and on The idea of pure rationality, I also arrive at a Christian interpretation of fact. An atheistic worldview is often a naturalistic worldview: essentially, there are only atoms and organic forces that we will evaluate.

‘That worries the synthetic cell, as Element of the Dutch BaSyC initiative. Craig Venter looked top rated-down in These times and discovered about five hundred genes that happen to be minimally required for the performing cell. We want to glance bottom-up: how do we go from the few molecules to a whole Organic system?

Electrical transportation in monolayers of phthalocyanine molecular wires and AFM imaging of a single wire bridging two electrodes

 Ultimately, I'll briefly sketch several of our Strategies to take a look at the building of synthetic cells, particularly our very first measures to ascertain synthetic cell division.